ContactMouse Biology ProgramUniversity of California 2795 Second Street Suite 400 Davis, CA 95618 530-757-3333 FAX 530-757-3284 mbp@ucdavis.edu 
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NewsJan 9th 2012: New MMRRC Strains.Dear Researchers,
The Mutant Mouse Regional Resource Centers (MMRRC) distributes and cryopreserves scientifically valuable, genetically engineered mouse strains and mouse ES cell lines with potential value for the genetics and biomedical research community. The MMRRC is a single repository with a national network of four breeding and distribution facilities coordinated by an information and service center. The MMRRC is supported by the National Institutes of Health Get ‘em while they last: The following Live colonies will be taken off the shelf this month. Once off the shelf, this strain will only be available as cryopreserved germplasm or mice from cryo recovery. Place your orders online by Tuesday, January 31 to receive mice from the Live colony.
The Repository’s newest additions: The following mouse models strains have recently been accepted and will be available through the MMRRC. If you register interest, we will notify you when the strain is available; you will then have the opportunity to place an order. The average wait time for a newly accepted strain to become available for distribution is seven months from time MMRRC receives it from the donor. To register interest, select the MMRRC stock number below, then click the star in the first column of the catalog.
View the newly accepted strains in the MMRRC catalog
MMRRC:036401-JAX, C3Fe;B6-Tbc1d14L5Jcs5/Mmjax MMRRC:036402-UCD, C57BL/6J-Pik3ap1m1Btlr/Mmcd MMRRC:036457-JAX, B6.129S4-Sagtm1Jnc Tg(Sag*3A240)2Seva/Mmjax MMRRC:036458-JAX, B6.129S4-Sagtm1Jnc Tg(Sag*3A50)1Seva/Mmjax MMRRC:036459-MU, B6.129S4-Sagtm1Jnc Tg(Sag*Tr12)2Seva/Mmmh MMRRC:036460-MU, B6.129S4-Sagtm1Jnc Tg(Sag*Tr4)1Seva/Mmmh MMRRC:036461-MU, B6.129S4-Sagtm1Jnc Tg(Sag)1Seva/Mmmh MMRRC:036462-UNC, B6.129S6-Pdx1tm1.2(CFP)Mgn/Mmnc MMRRC:036463-UNC, STOCK-Sox17tm1.3(Cre.GFP)Mgn/Mmnc MMRRC:036464-UCD, 129S-Hfe2tm2Nca/Mmcd MMRRC:036465-UCD, STOCK Tg(Lgals1-EGFP)OA32Gsat/Mmcd MMRRC:036466-UCD, STOCK Tg(Nrp2-EGFP)SH25Gsat/Mmcd MMRRC:036467-UCD, STOCK Tg(Peg10-EGFP)OD131Gsat/Mmcd MMRRC:036468-UCD, STOCK Tg(Pcp2-TOM)PK9Gsat/Mmcd MMRRC:036469-UCD, STOCK Tg(Chrnb3-cre)SM93Gsat/Mmcd MMRRC:036470-UCD, STOCK Tg(Ebf2-cre)NP183Gsat/Mmcd MMRRC:036471-UCD, STOCK Tg(Nr5a1-cre)SB15Gsat/Mmcd MMRRC:036472-UCD, STOCK Tg(Pde1b-cre)OZ114Gsat/Mmcd MMRRC:036473-UCD, STOCK Tg(Shf-cre)SO5Gsat/Mmcd MMRRC:036474-UNC, B6.129P2-Kdm3atm1.1Yzha/Mmnc MMRRC:036475-UCD, 129S6.Cg-Tg(Krt14-TFRC)#Lmil/Mmcd Donate your Strain: The mouse models you have created are a valuable resource. Please consider submitting your strain to make it available for distribution to the scientific community We strongly encourage donating modified MMRRC strains and/or mice made from MMRRC ES cells. Providing a published paper, in-press manuscript, or access to your phenotype data, will guarantee acceptance and archiving of your strain with the MMRRC. Terms and Benefits of submitting to the MMRRC. Please direct questions to MMRRC Customer Service at: service@mmrrc.org Phone: 800.910.2291 (North America) or +1.530.757.5710 (International).
Sep 29th 2011: $34 million grant awarded to create mouse models of human diseasesA consortium of U.S. and Canadian health science partners, including the University of California, Davis, has been awarded $34 million in grants by the National Institutes of Health to support creation of mouse models of such human diseases as cancer, obesity, diabetes and heart disease. The new five-year cooperative agreement funds the second phase of the Knockout Mouse Project — or KOMP — first funded by the NIH in 2006. Knockout mice are genetically customized mice that have individual genes turned off or “knocked out,” or have a gene ramped up, to make them either more prone or more resistant to specific diseases. “In this consortium, we have assembled world experts in mouse stem cell biology, genetics, breeding, and phenotypic analysis who are dedicated to ensuring the successful outcome of KOMP2, on time and on budget,” said Kent Lloyd, director of the UC Davis Mouse Biology Program and principal investigator and director of the newly funded project. Lloyd is also a professor of anatomy, physiology and cell biology at the UC Davis School of Veterinary Medicine, and serves as the school’s associate dean for research.
Sep 20th 2011: Education App from NHGRINHGRI has developed its first education ‘App’! If you use an iPhone, iPad, or iPod Touch, you can now have free access to the popular NHGRI Talking Glossary of Genetics anywhere you go. In addition to offering easy-to-understand written definitions, users can listen to an NHGRI scientist explain each term and provide contextual learning tips. The glossary App contains nearly 200 color illustrations and more than thirty 3-D animations that illustrate genetic concepts. The mobile version of the glossary includes all of the bells and whistles of the online version, including new and simplified search methods, easy-to-find terms of interest, alphabetical navigation to search functions, and lists of related terms. There’s even a “Test Your Gene Knowledge” quiz, so users can check their understanding of the glossary’s contents. The majority of the glossary terms are studied in middle school, high school, and collegiate science classes. Teachers at all levels were used to help compile the terms and evaluate the glossary during development. It’s free and it’s fun. Either go to the iTunes App Store and search “talking glossary” or click on the App Store link below. http://itunes.apple.com/us/app/talking-glossary-of-genetics/id428340581?mt=8&ls=1 Sep 8th 2011: New MMRRC StrainsDear Researchers, The Mutant Mouse Regional Resource Centers (MMRRC) distributes and cryopreserves scientifically valuable, genetically engineered mouse strains and mouse ES cell lines with potential value for the genetics and biomedical research community. The MMRRC is a single repository with a national network of four breeding and distribution facilities coordinated by an information and service center. The MMRRC is supported by the National Institutes of Health Get ‘em while they last: The following Live colonies will be taken off the shelf at the end of this month. Once off the shelf, the live mice will only be available as a resuscitation. MMRRC:000011, STOCK Mecp2tm1.1Jae/Mmcd Research applications include: mouse model for Rett Syndrome. This strain is available congenic on a C57BL/6J background as B6.Cg-Mecp2tm1.1Jae/Mmcd, MMRRC:000415 Now available for Distribution: 18 mouse models are newly available from the MMRRC repository. Strain Detail Sheets for each of these strains can be accessed through the stock numbers below or the MMRRC’s. MMRRC:034828, C3B6-Tg(APP695)3Dbo/Mmjax Research applications include: models for human disease and neurobiology MMRRC:034829, B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax Research applications include: cancer, cardiovascular, endocrine deficiency, metabolism, models for human disease, neurobiology, reproduction. MMRRC:034830, B6;129-Psen1tm1MpmTg(APPSwe,tauP301L)1Lfa/Mmjax Research applications include: models for human disease, neurobiology. MMRRC:034831, B6.129-Tg(APPSw)40Btla/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034832, B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034833, B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034834, B6C3-Tg(tetO-APPSwInd)885Dbo/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034835, B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034836, B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2J/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034837, B6.129S4-Tg(APPSwLon)96Btla/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034838, 129S1.129(Cg)-Tg(APPSw)40Btla/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034839, D2.129(B6)-Tg(APPSw)40Btla/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034840, B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034841, A.129(B6)-Tg(APPSw)40Btla/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034842, B6;C3-Tg(Prnp-ITM2B/APP695*42)A12Emcg/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034843, C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034844, B6.Cg-Tg(tetO-APPSwInd)885Dbo/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034845, B6.Cg-Tg(tetO-APPSwInd)102Dbo/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034846, B6.Cg-Tg(tetO-APPSwInd)107Dbo/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034848, B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax Research applications include: models for human disease, neurobiology MMRRC:034849, B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax Research applications include: models for human disease, neurobiology MMRRC:036053, STOCK Tg(tetO-HCV)1Mlch/Mmjax Research applications include: diabetes/obesity, metabolism, virology MMRRC:036055, B6.FVB(Cg)-Tg(Slc6a5-cre)KF109Gsat/Mmcd BAC Cre expression driven by Slc6a5 promoter with very specific expression in glycinergic neurons in brainstem MMRRC:036056, B6.FVB(Cg)-Tg(Cdhr1-cre)KG66Gsat/Mmcd BAC Cre expression driven by Cdhr1 promoter with expression noted in olfactory bulb mitral cells with projections to piriform cortex MMRRC:036119, B6.129-Gp2tm1Awl/Mmcd Research applications include: intestinal mucosal immunology; Peyer’s patch; M cells; host:bacteria interactions MMRRC:036158, B6.FVB(Cg)-Tg(Adora2a-cre)KG139Gsat/Mmcd BAC Cre expression driven by Adora2a promoter with expression noted in the striatum: indirect pathway (striatopallidal, Drd2) specific The Repository’s newest additions: The following 10 strains have recently been accepted and will be available through the MMRRC. If you register interest, we will notify you when the strain is available; you will then have the opportunity to place an order. The average wait time for a newly accepted strain to become available for distribution is seven months from time MMRRC receives it from the donor. To register interest, select the MMRRC stock number below, then click the star in the first column. MMRRC:036108, C57BL/6-Cpm1Btlr/Mmcd Also known as iron10. Research applications include: iron homeostasis, hemochromatosis, models aceruloplasminemia in humans MMRRC:036109, C57BL/6-Cd22m1Btlr/Mmcd Also known as well. Research applications include: BCR signaling, autoimmunity, sialic acids MMRRC:036110, B6.SJL(Cg) Tg(H-2Kb-p80HT)808/Hfdg/Mmjax Research applications include: NF-kB2; lymphoma; lymphocyte development; cell survival, model for human lymphomas that carry NF-kB2 MMRRC:036111, B6.SJL(Cg) Tg(H-2Kb-NFkB2)452Hfdg/Mmjax Research applications include: NF-kB2, autoimmune disease, B cell development, model for human autoimmune diseases as the result of aberrant activation of the NF-kB2 signaling pathway MMRRC:036112, B6;129SP2-Mrgprdtm4.1(COP4)Mjz/Mmnc Research applications include: nociception, neuroscience, neurobiology MMRRC:036113, C57BL/6-Dock2m1Btlr/Mmmh Also known as frazz. Research applications include: T-dependent humoral immunity, B cell development MMRRC:036114, C57BL/6-Dock2m2Btlr/Mmmh Also known as frizz. Research applications include: T-dependent humoral immunity, B cell development MMRRC:036115, C57BL/6-Eif2ak4m2Btlr/Mmmh Also known as atchoum. Research applications include: MCMV, viral infection, eIF2alpha kinase, viral susceptibility MMRRC:036116, B6.Cg-Mapttm1Hnd Tg(MAPT)Gsd/Mmjax Research applications include: Alzheimer’s disease, frontotemporal dementia, tau, tauopathy, 3-repeat and 4-repeat tau MMRRC:036118, B6;129S1-Mrgprdtm1.1(cre)And/Mmnc Research applications include: nociception, neuroscience, neurobiology If you have questions, please contact MMRRC Customer Service at: * E-mail: service@mmrrc.org * Phone: 800.910.2291 (North America) or +1.530.757.5710 (International) Have you generated a mouse from an ES cell line obtained from the MMRRC? Submit your strain and make it available for distribution to the scientific community. If you can provide a published paper, in-press manuscript, or access to your phenotype data, we will guarantee acceptance and archiving of your strain with the MMRRC. Beth Page Repository Curator MMRRC, ICSC University of California, Davis Aug 17th 2011: Core Facilities: Maximizing the Return on InvestmentA commentary by Gregory Farber and Linda Weiss entitled ‘Core Facilities: Maximizing the Return on Investment, appears in this week’s online version of Science Translational Medicine (Volume 3, Issue 95, page 95, August 10, 2011) at http://stm.sciencemag.org/content/3/95/95cm21.abstract . From the posted abstract…”To conduct high-quality state-of-the-art research, clinical and translational scientists need access to specialized core facilities and appropriately trained staff. In this time of economic constraints and increasing research costs, organized and efficient core facilities are essential for researchers who seek to investigate complex translational research questions. Here, we describe efforts at the U.S. National Institutes of Health and academic medical centers to enhance the utility of cores.”
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