May 03 2012 – The Center for Genomic Pathology and UC Davis Extension announce a new course in the online series Pathobiology of the Mouse: Mouse as a Model for Mammary Cancer. This groundbreaking course is the first in the second tier of the program and is designed for experienced investigators at the doctoral level working in mammary tumor biology. The course includes case studies and interactive conferences with expert faculty. Now open for enrollment, the course is scheduled to launch on June 11, 2012 Press Release
ContactMouse Biology ProgramUniversity of California 2795 Second Street Suite 400 Davis, CA 95618 530-757-3333 FAX 530-757-3284 mbp@ucdavis.edu 
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May 12, 2012March 26, 2012Mouse Strains Newly Available from the MMRRC
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in the left hand column.| MMRRC:012034-UNC | B6;129X1-Msratm1Jmo/Mmnc | |
| MMRRC:016981-UNC | STOCK Myh10tm7Rsad/Mmnc | |
| MMRRC:036119-UCD | B6.129-Gp2tm1Awl/Mmcd |
The Repository’s newest additions: The following mouse models strains have recently been accepted and will be available through the MMRRC. If you register interest, we will notify you when the strain is available; you will then have the opportunity to place an order. The average wait time for a newly accepted strain to become available for distribution is seven months from time MMRRC receives it from the donor.
To register interest, select the MMRRC stock number below, then click the star in the first column of the catalog.
View the newly accepted strains in the MMRRC catalog
MMRRC:036401-JAX, C3Fe;B6-Tbc1d14L5Jcs5/Mmjax
Research applications include: Developmental Biology
MMRRC:036402-UCD, C57BL/6J-Pik3ap1m1Btlr/Mmcd
Research applications include: Immunology and Inflammation
MMRRC:036457-JAX, B6.129S4-Sagtm1Jnc Tg(Sag*3A240)2Seva/Mmjax
Research applications include: Sensorineural
MMRRC:036458-JAX, B6.129S4-Sagtm1Jnc Tg(Sag*3A50)1Seva/Mmjax
Research applications include: Sensorineural
MMRRC:036459-MU, B6.129S4-Sagtm1Jnc Tg(Sag*Tr12)2Seva/Mmmh
Research applications include: Sensorineural
MMRRC:036460-MU, B6.129S4-Sagtm1Jnc Tg(Sag*Tr4)1Seva/Mmmh
Research applications include: Sensorineural
MMRRC:036461-MU, B6.129S4-Sagtm1Jnc Tg(Sag)1Seva/Mmmh
Research applications include: Sensorineural
MMRRC:036462-UNC, B6.129S6-Pdx1tm1.2(CFP)Mgn/Mmnc
Research applications include: Internal/Organ, Diabetes/Obesity, Research Tools
MMRRC:036463-UNC, STOCK-Sox17tm1.3(Cre.GFP)Mgn/Mmnc
Research applications include: Internal/Organ, Diabetes/Obesity, Research Tools
MMRRC:036464-UCD, 129S-Hfe2tm2Nca/Mmcd
Research applications include: Neurobiology, Developmental Biology, Models for Human Disease, Cardiovascular, Research Tools, Hematology
MMRRC:036465-UCD, STOCK Tg(Lgals1-EGFP)OA32Gsat/Mmcd
Research applications include: Developmental Biology, Research Tools, Cell Biology, Neurobiology
MMRRC:036466-UCD, STOCK Tg(Nrp2-EGFP)SH25Gsat/Mmcd
Research applications include: Neurobiology, Developmental Biology, Research Tools, Cell Biology
MMRRC:036467-UCD, STOCK Tg(Peg10-EGFP)OD131Gsat/Mmcd
Research applications include: Developmental Biology, Research Tools, Cell Biology, Neurobiology
MMRRC:036468-UCD, STOCK Tg(Pcp2-TOM)PK9Gsat/Mmcd
Research applications include: Neurobiology, Developmental Biology, Research Tools, Cell Biology
MMRRC:036469-UCD, STOCK Tg(Chrnb3-cre)SM93Gsat/Mmcd
Research applications include: Developmental Biology, Research Tools, Cell Biology, Neurobiology
MMRRC:036470-UCD, STOCK Tg(Ebf2-cre)NP183Gsat/Mmcd
Research applications include: Neurobiology, Developmental Biology, Research Tools, Cell Biology
MMRRC:036471-UCD, STOCK Tg(Nr5a1-cre)SB15Gsat/Mmcd
Research applications include: Developmental Biology, Research Tools, Cell Biology, Neurobiology
MMRRC:036472-UCD, STOCK Tg(Pde1b-cre)OZ114Gsat/Mmcd
Research applications include: Neurobiology, Developmental Biology, Research Tools, Cell Biology
MMRRC:036473-UCD, STOCK Tg(Shf-cre)SO5Gsat/Mmcd
Research applications include: Developmental Biology, Research Tools, Cell Biology, Neurobiology
MMRRC:036474-UNC, B6.129P2-Kdm3atm1.1Yzha/Mmnc
Research applications include: Reproduction, Cardiovascular, Diabetes/Obesity, Developmental Biology
MMRRC:036475-UCD, 129S6.Cg-Tg(Krt14-TFRC)#Lmil/Mmcd
Research applications include: Internal/Organ, Dermatology, Models for Human Disease, Immunology and Inflammation, Cell Biology, Metabolism, Hematology, Cancer, Research Tools
Donate your Strain: The mouse models you have created are a valuable resource. Please consider submitting your strain to make it available for distribution to the scientific community
We strongly encourage donating modified MMRRC strains and/or mice made from MMRRC ES cells. Providing a published paper, in-press manuscript, or access to your phenotype data, will guarantee acceptance and archiving of your strain with the MMRRC.
Terms and Benefits of submitting to the MMRRC.
Please direct questions to MMRRC Customer Service at: service@mmrrc.org
Phone: 800.910.2291 (North America) or +1.530.757.5710 (International).
September 29, 2011
$34 million grant awarded to create mouse models of human diseases
A consortium of U.S. and Canadian health science partners, including the University of California, Davis, has been awarded $34 million in grants by the National Institutes of Health to support creation of mouse models of such human diseases as cancer, obesity, diabetes and heart disease.
The new five-year cooperative agreement funds the second phase of the Knockout Mouse Project — or KOMP — first funded by the NIH in 2006. Knockout mice are genetically customized mice that have individual genes turned off or “knocked out,” or have a gene ramped up, to make them either more prone or more resistant to specific diseases.
“In this consortium, we have assembled world experts in mouse stem cell biology, genetics, breeding, and phenotypic analysis who are dedicated to ensuring the successful outcome of KOMP2, on time and on budget,” said Kent Lloyd, director of the UC Davis Mouse Biology Program and principal investigator and director of the newly funded project. Lloyd is also a professor of anatomy, physiology and cell biology at the UC Davis School of Veterinary Medicine, and serves as the school’s associate dean for research.
September 20, 2011
Education App from NHGRI
NHGRI has developed its first education ‘App’!
If you use an iPhone, iPad, or iPod Touch, you can now have free access to the popular NHGRI Talking Glossary of Genetics anywhere you go.
In addition to offering easy-to-understand written definitions, users can listen to an NHGRI scientist explain each term and provide contextual learning tips. The glossary App contains nearly 200 color illustrations and more than thirty 3-D animations that illustrate genetic concepts. The mobile version of the glossary includes all of the bells and whistles of the online version, including new and simplified search methods, easy-to-find terms of interest, alphabetical navigation to search functions, and lists of related terms.
There’s even a “Test Your Gene Knowledge” quiz, so users can check their understanding of the glossary’s contents.
The majority of the glossary terms are studied in middle school, high school, and collegiate science classes. Teachers at all levels were used to help compile the terms and evaluate the glossary during development.
It’s free and it’s fun. Either go to the iTunes App Store and search “talking glossary” or click on the App Store link below.
http://itunes.apple.com/us/app/talking-glossary-of-genetics/id428340581?mt=8&ls=1
September 8, 2011
New MMRRC Strains
Dear Researchers,
The Mutant Mouse Regional Resource Centers (MMRRC) distributes and cryopreserves scientifically valuable, genetically engineered mouse strains and mouse ES cell lines with potential value for the genetics and biomedical research community. The MMRRC is a single repository with a national network of four breeding and distribution facilities coordinated by an information and service center. The MMRRC is supported by the National Institutes of Health
Get ‘em while they last: The following Live colonies will be taken off the shelf at the end of this month. Once off the shelf, the live mice will only be available as a resuscitation.
MMRRC:000011, STOCK Mecp2tm1.1Jae/Mmcd
Research applications include: mouse model for Rett Syndrome. This strain is available congenic on a C57BL/6J background as B6.Cg-Mecp2tm1.1Jae/Mmcd, MMRRC:000415
Now available for Distribution: 18 mouse models are newly available from the MMRRC repository. Strain Detail Sheets for each of these strains can be accessed through the stock numbers below or the MMRRC’s.
MMRRC:034828, C3B6-Tg(APP695)3Dbo/Mmjax
Research applications include: models for human disease and neurobiology
MMRRC:034829, B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
Research applications include: cancer, cardiovascular, endocrine deficiency, metabolism, models for human disease, neurobiology, reproduction.
MMRRC:034830, B6;129-Psen1tm1MpmTg(APPSwe,tauP301L)1Lfa/Mmjax
Research applications include: models for human disease, neurobiology.
MMRRC:034831, B6.129-Tg(APPSw)40Btla/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034832, B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034833, B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034834, B6C3-Tg(tetO-APPSwInd)885Dbo/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034835, B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034836, B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2J/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034837, B6.129S4-Tg(APPSwLon)96Btla/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034838, 129S1.129(Cg)-Tg(APPSw)40Btla/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034839, D2.129(B6)-Tg(APPSw)40Btla/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034840, B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034841, A.129(B6)-Tg(APPSw)40Btla/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034842, B6;C3-Tg(Prnp-ITM2B/APP695*42)A12Emcg/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034843, C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034844, B6.Cg-Tg(tetO-APPSwInd)885Dbo/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034845, B6.Cg-Tg(tetO-APPSwInd)102Dbo/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034846, B6.Cg-Tg(tetO-APPSwInd)107Dbo/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034848, B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:034849, B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
Research applications include: models for human disease, neurobiology
MMRRC:036053, STOCK Tg(tetO-HCV)1Mlch/Mmjax
Research applications include: diabetes/obesity, metabolism, virology
MMRRC:036055, B6.FVB(Cg)-Tg(Slc6a5-cre)KF109Gsat/Mmcd
BAC Cre expression driven by Slc6a5 promoter with very specific expression in glycinergic neurons in brainstem
MMRRC:036056, B6.FVB(Cg)-Tg(Cdhr1-cre)KG66Gsat/Mmcd
BAC Cre expression driven by Cdhr1 promoter with expression noted in olfactory bulb mitral cells with projections to piriform cortex
MMRRC:036119, B6.129-Gp2tm1Awl/Mmcd
Research applications include: intestinal mucosal immunology; Peyer’s patch; M cells; host:bacteria
interactions
MMRRC:036158, B6.FVB(Cg)-Tg(Adora2a-cre)KG139Gsat/Mmcd
BAC Cre expression driven by Adora2a promoter with expression noted in the striatum: indirect pathway (striatopallidal, Drd2) specific
The Repository’s newest additions: The following 10 strains have recently been accepted and will be available through the MMRRC. If you register interest, we will notify you when the strain is available; you will then have the opportunity to place an order. The average wait time for a newly accepted strain to become available for distribution is seven months from time MMRRC receives it from the donor.
To register interest, select the MMRRC stock number below, then click the star in the first column.
MMRRC:036108, C57BL/6-Cpm1Btlr/Mmcd
Also known as iron10. Research applications include: iron homeostasis, hemochromatosis, models aceruloplasminemia in humans
MMRRC:036109, C57BL/6-Cd22m1Btlr/Mmcd
Also known as well. Research applications include: BCR signaling, autoimmunity, sialic acids
MMRRC:036110, B6.SJL(Cg) Tg(H-2Kb-p80HT)808/Hfdg/Mmjax
Research applications include: NF-kB2; lymphoma; lymphocyte development; cell survival, model for human lymphomas that carry NF-kB2
MMRRC:036111, B6.SJL(Cg) Tg(H-2Kb-NFkB2)452Hfdg/Mmjax
Research applications include: NF-kB2, autoimmune disease, B cell development, model for human autoimmune diseases as the result of aberrant activation of the NF-kB2 signaling pathway
MMRRC:036112, B6;129SP2-Mrgprdtm4.1(COP4)Mjz/Mmnc
Research applications include: nociception, neuroscience, neurobiology
MMRRC:036113, C57BL/6-Dock2m1Btlr/Mmmh
Also known as frazz. Research applications include: T-dependent humoral immunity, B cell development
MMRRC:036114, C57BL/6-Dock2m2Btlr/Mmmh
Also known as frizz. Research applications include: T-dependent humoral immunity, B cell development
MMRRC:036115, C57BL/6-Eif2ak4m2Btlr/Mmmh
Also known as atchoum. Research applications include: MCMV, viral infection, eIF2alpha kinase, viral susceptibility
MMRRC:036116, B6.Cg-Mapttm1Hnd Tg(MAPT)Gsd/Mmjax
Research applications include: Alzheimer’s disease, frontotemporal dementia, tau, tauopathy, 3-repeat and
4-repeat tau
MMRRC:036118, B6;129S1-Mrgprdtm1.1(cre)And/Mmnc
Research applications include: nociception, neuroscience, neurobiology
If you have questions, please contact MMRRC Customer Service at:
* E-mail: service@mmrrc.org
* Phone: 800.910.2291 (North America) or +1.530.757.5710 (International)
Have you generated a mouse from an ES cell line obtained from the MMRRC? Submit your strain and make it available for distribution to the scientific community. If you can provide a published paper, in-press manuscript, or access to your phenotype data, we will guarantee acceptance and archiving of your strain with the MMRRC.
Beth Page
Repository Curator
MMRRC, ICSC
University of California, Davis
August 17, 2011
Core Facilities: Maximizing the Return on Investment
A commentary by Gregory Farber and Linda Weiss entitled ‘Core Facilities: Maximizing the Return on Investment, appears in this week’s online version of Science Translational Medicine (Volume 3, Issue 95, page 95, August 10, 2011) at http://stm.sciencemag.org/content/3/95/95cm21.abstract . From the posted abstract…”To conduct high-quality state-of-the-art research, clinical and translational scientists need access to specialized core facilities and appropriately trained staff. In this time of economic constraints and increasing research costs, organized and efficient core facilities are essential for researchers who seek to investigate complex translational research questions. Here, we describe efforts at the U.S. National Institutes of Health and academic medical centers to enhance the utility of cores.”
July 5, 2011
Mouse Genetics 2011 presentations
The Mouse Biology Program presented the following posters and platform presentation at the Mouse Genetics 2011 meeting in Washington D.C.
June 23, 2011
Mouse Genetics 2011 Now!
The Mouse Genetics 2011 meeting is in progress right now at Washington D.C. The KOMP Repository and Mouse Biology Program invites you to visit our booth(#206), discover the products/services we have to offer and grab some free souvenirs!
June 3, 2011
Mouse Molecular Genetics ( 20-23 September 2011 )
For the past 24 years, the Mouse Molecular Genetics meeting has been a leading forum for researchers who apply the methods of genetics and genomics to fundamental problems in mammalian biology, including from stem cell biology, early development, and models of human disease. In particular, the meeting showcases the latest technical developments in genetics and engineering of the mouse genome, and this year will feature a session devoted to imaging. The Mouse Molecular Genetics meeting assembles leaders in the field to present unpublished research findings, encourages junior investigators to participate in oral and poster presentations, and provides a stimulating environment for the exchange of ideas and information.